DNA replication, chromatin and cell division
Genome Dynamics and Function
Centro de Biología Molecular “Severo Ochoa” CSIC-UAM (CBMSO)
DESCRIPTION OF THE OFFER
We are interested in understanding how this coordination is established during development by studying cell division, DNA replication and gene expression control, as well as the implications of epigenetics. To that end, we use the model plant Arabidopsis thaliana that allows molecular, cellular, genetic and genomic approaches. Both conceptually and technically, Arabidopsis is a powerful model to tackle questions that have not or cannot be addressed easily in other model systems. Thus our organismal approaches are aimed at uncovering fundamental concepts of cell cycle control, cell homeostasis and genome duplication in multicellular organisms.
DNA replication and epigenetics
Chromatin replication and histone dynamics
Cell division and cell fate control
25 Years of Cell Cycle Research: What's Ahead? Gutierrez C. Trends Plant Sci. 2016 Jul 8. pii: S1360-1385(16)30072-3. doi: 10.1016/j.tplants.2016.06.007.
Histone H3 Dynamics Reveal Domains with Distinct Proliferation Potential in the Arabidopsis Root. Otero S, Desvoyes B, Peiró R, Gutierrez C. Plant Cell. 2016 Jun;28(6):1361-71. doi: 10.1105/tpc.15.01003.
Links between genome replication and chromatin landscapes. Sequeira-Mendes J, Gutierrez C. Plant J. 2015 Jul;83(1):38-51. doi: 10.1111/tpj.12847.
Looking at plant cell cycle from the chromatin window. Desvoyes B, Fernández-Marcos M, Sequeira-Mendes J, Otero S, Vergara Z, Gutierrez C. Front Plant Sci. 2014 Jul 25;5:369. doi: 10.3389/fpls.2014.00369
Biomolecules & Cell D.