Genoxphos

Cardiovascular diseases remain the major cause of death in the developed word. Mitochondrial physiology biogenesis are deeply involved in the initiation progression of the disease, through reactive oxygen species (ROS) production, energy deficiency decrease in mitochondrial respirasome formation, as initial steps in the formation of the plaques. This project aims better understand the involvement of mitochondria in cardiomyopathies using different models of mitochondrial diseases that curses with increase ROS production.

2 YEARS PUBLICATIONS

1. Ana Latorre-Pellicer, Raquel Moreno-Loshuertos, Ana Victoria Lechuga-Vieco, Fátima Sánchez-Cabo, Carlos Torroja, Rebeca Acín-Pérez, Enrique Calvo, Esther Aix, Andrés González-Guerra, Angela Logan, María Luisa Bernad-Miana, Eduardo Romanos, Raquel Cruz, Sara Cogliati, Beatriz Sobrino, Ángel Carracedo, Acisclo Pérez-Martos, Patricio Fernández-Silva, Jesús Ruíz-Cabello, Michael P. Murphy, Ignacio Flores, Jesús Vázquez and José Antonio Enríquez. (2016) mtDNA and nuclear DNA matching shapes metabolism and healthy ageing. Nature 2016 Jul 6. doi: 10.1038/nature18618.
2. Moreno-Loshuertos, R. and Enriquez, J.A. (2016) Respiratory Supercomplexes and the functional segmentation of the CoQ pool Free Radical Biology and Medicine. 2016 Apr 19. pii: S0891-5849(16)30037-5
3. Gómez-del Arco, P., Perdiguero, E., Yunes-Leites, P.S., Acín-Pérez, R., Zein, M., García-Gómez, A., Krishnamoorthy, S., Jiménez-Alcázar, Segalés, J., B., López-Maderuelo, D., Ornés, Jiménez-Borreguero, L.J., D´Amato, G., Enshell-Seijffers, D., Morgan, B., Georgopoulos, K., Islam, A.B.M.M.K., Kim, J., Braun, T., de la Pompa, J.L.Kim, J., Enriquez, J.A., Ballestar, E., Muñoz-Cánoves, P. and Redondo, J.M. (2016) The Chromatin Remodeling Complex Chd4/NuRD controls striated muscle identity and metabolic homeostasis. Cell Metab. (in Press).
4. Scialo, F., Sriram, A., Fernández-Ayala, D., Gubina, N., Lõhmus, M., Nelson, G., Logan, A., Cooper, H.M., Navas, P., Enriquez, J.A., Murphy, M.P. and Sanz, A. (2016). Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 23, 725–734.
5. Guarás, A., Perales-Clemente, E., Calvo, E., Acín-Peréz, R., Loureiro-Lopez, M., Pujol, C., Martínez-Carrascoso, I., Nunez, E., García-Marqués, F., Rodriguez-Hernandez, M.A., Cortés, A., Díaz, F., Pérez-Martos, A., Moraes, C.T., Fernández-Silva, P., Trifunivic, A., Navas, P., Vázquez, J. and Enriquez, J.A. (2016). The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency. Cell Reports 15, 197–209.
6. Cogliati, S., Enriquez, J.A., and Scorrano, L. (2016). Mitochondrial Cristae: Where Beauty Meets Functionality. Trends Biochem. Sci. 41, 261–273.
7. Enriquez, J.A. (2016) Supramolecular Organization of Respiratory Complexes. Annu. Rev. Physiol. 78, 533-561
8. Pellico, J., Ruiz-Cabello, J., Saiz-Alía, M., Del Rosario, G., Caja, S., Montoya, M., Fernández de Manuel, L., Morales, M.P., Gutiérrez, L., Galiana, B., Enriquez, J.A. and Herranz, F. (2016). Fast synthesis and bioconjugation of (68) Ga core-doped extremely small iron oxide nanoparticles for PET/MR imaging. Contrast Media Mol Imaging. in press DOI: 10.1002/cmmi.1681
9. Baixauli, F., Acín-Peréz, R., Villarroya-Beltri, C., Mazzeo, C., Nunez-Andrade, N., Gabande-Rodriguez, E., Ledesma, M.D., Blázquez, A., Martín, M.A., Falcon- Perez, J.M., Redondo, J.M., Enriquez, J.A. and Mittelbrunn, M (2015). Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses. Cell Metab. 22, 485–498.
10. Cagin, U., and Enriquez, J.A. (2015). The complex crosstalk between mitochondria and the nucleus: What goes in between? Int J Biochem Cell Biol 63, 10–15.
11. Tawakol, A., Singh, P., Mojena, M., Pimentel-Santillana, M., Emami, H., MacNabb, M., Rudd, J.H.F., Narula, J., Enriquez, J.A., Través, P.G., Fernández-Velasco, M., Bartrons, R., Martín-Sánz, P., Fayad, A.A., Tejedor, A. and Boscá, L. (2015). HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages. Arterioscler Thromb Vasc Biol 35, 1463–1471.
12. Jourdain, A.A., Koppen, M., Rodley, C.D., Maundrell, K., Gueguen, N., Reynier, P., Guaras, A.M., Enriquez, J.A., Anderson, P., Simarro, M. and Martinou, J-C. (2015). A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function. Cell Reports 10, 1110–1121.
13. Catalán, E., Charni, S., Jaime, P., Aguiló, J.I., Enriquez, J.A., Naval, J., Pardo, J., Villalba, M., and Anel, A. (2015). MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells. OncoImmunology 4, e985924
14. Bretón-Romero, R., Acín-Peréz, R., Rodríguez-Pascual, F., Martínez-Molledo, M., Brandes, R.P., Rial, E., Enriquez, J.A., and Lamas, S. (2014). Laminar shear stress regulates mitochondrial dynamics, bioenergetics responses and PRX3 activation in endothelial cells. Biochim Biophys Acta 1843, 2403–2413.
15. 14. Moreno, V., Gonzalo, P., Gómez-Escudero, J., Pollán, A., Acín-Peréz, R., Breckenridge, M., Yáñez-Mó, M., Barreiro, O., Orsenigo, F., Kadomatsu, K., Chen, C.S., Enriquez, J.A., Dejana, E., Sánchez-Madrid, F. and Arroyo, A.G. (2014). An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. J Cell Sci 127, 3768–3781.
16. Quirós, P.M., Español, Y., Acín-Peréz, R., Rodríguez, F., Bárcena, C., Watanabe, K., Calvo, E., Loureiro, M., Fernández-García, M.S., Fueyo, A., Vazquez, J., Enriquez, J.A. and López-Otín, C. (2014). ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity. Cell Reports 8, 542–556.
17. Wolff, J.N., Ladoukakis, E.D., and Dowling, D.K. (2014). Mitonuclear interactions: evolutionary consequences over multiple biological scales. Philos Trans R Soc Lond, B, Biol Sci 369, 20130443–20130443.
18. Enriquez, J.A. and Lenaz, G. (2014). Coenzyme q and the respiratory chain: coenzyme q pool and mitochondrial supercomplexes. Mol. Syndromol. 5: 119-140
19. Acín-Peréz, R., Carrascoso, I., Baixauli, F., Roche-Molina, M., Latorre-Pellicer, A., Fernández-Silva, P., Mittelbrunn, M., Sánchez-Madrid, F., Pérez-Martos, A., Lowell, C.A., Manfredi,G. and Enriquez, J.A. (2014). ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use. Cell Metab. 19, 1020–1033.
20. Beninca, C., Planagumà, J., de Freitas Shuck, A., Acín-Peréz, R., Muñoz, J.P., de Almeida, M.M., Brown, J.H., Murphy, A.N., Zorzano, A., Enriquez, J.A. and Aragy, A. (2014). A new non-canonical pathway of Gα(q) protein regulating mitochondrial dynamics and bioenergetics. Cell Signal 26, 1135–1146.
21. Acín-Peréz, R., and Enriquez, J.A. (2014). The function of the respiratory supercomplexes: the plasticity model. Biochim Biophys Acta 1837, 444–450.