Smart Biomaterials Research Group (UCM)

This project aims to develop a new approach for the production of nanoparticles and to explore them as new drug delivery systems. During this TFM, mesoporous silica nanoparticles, which have a high loading capacity and controllable drug release, will be synthesised and coated with different lipid membranes from different cell lines, such as human mesenchymal cells. Their ability to transport and release certain therapeutic agents into the cytoplasm of different cells will be evaluated. Their potential use to reverse certain pathological conditions, such as osteoporosis, will be evaluated.
The student will carry out most of the procedures necessary to achieve the aforementioned objectives, such as synthesis and characterisation of the nanoparticles, functionalisation and characterisation of their surface, optimisation of the loading with different therapeutic agents, study of the release of the transported charge and evaluation of the effects produced in different cell models.