Chemokine receptors: new targets for therapeutic intervention

The Master's thesis (TFM) will deal with the study of the importance chemokine receptor dynamics in the cell membrane.  Using total internal reflection microscopy (TIRF) and various cell migration assays we will analyze how the behavior of CCR7 depends on its interaction with different ligands and cell type.  These studies will be completed with biochemical assays that will help us to understand the signaling pathways involved in CCR7 function.