Laboratory of Molecular and Genetic Cardiovascular Pathophysiology
Cardiovascular Biology and Cardiovascular Diseases
Centro Nacional de Investigaciones Cardiovasculares "Carlos III" (CNIC)
DESCRIPTION OF THE OFFER
Cardiovascular disease (CVD) is the main health and socio-economic problem worldwide, in part due to the progressive aging that the world population is experiencing. Atherosclerosis and heart failure contribute significantly to CVD-related morbimortality in the elderly. These anomalies and the aging process are much accelerated in Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder (prevalence about 1 in 18 million) caused by the expression of progerin, a mutant form of lamin A. The most serious aspect of HGPS is extensive atherosclerosis and cardiac electrophysiological alterations which are associated with early death (average lifespan: 14.6 yr), predominantly from myocardial infarction or stroke. Progerin is also expressed at low level in aged tissues of non-HGPS individuals, suggesting a role in normal aging. Understanding how progerin causes CVD and premature aging may therefore shed light on normal aging.
Our research currently focuses on:
- Identifying mechanisms through which wild-type lamin A/C regulate CVD.
- Identifying systemic and tissue-specific factors and extracellular matrix alterations that contribute to HGPS and associated CVD, and the underlying molecular and cellular mechanisms, to identify new therapeutic targets.
- Generating a porcine model of HGPS for preclinical translational research.
Biomolecules & Cell D.
Vicente Andrés García