Molecular Mechanisms of sex-differences in metabolism physiology and disease
Metabolism and Cell Signaling
Centro de Biología Molecular “Severo Ochoa” CSIC-UAM (CBMSO)
DESCRIPTION OF THE OFFER
As part of the progress towards personalized medicine, there is an urgent need to understand biological sex-differences. However, the progress in the understanding of the sex-specific physio-pathology is still marginal. Our laboratory aims to understand the molecular mechanisms of metabolic sex-differences in health and disease, explicitly exploring mitochondria’s role. Indeed, mitochondria are the central hub of metabolism and targets of sexual-hormones, with a suggested role in modulating sex-specific differences in many physio-pathological conditions. Currently, we are running a project to define the mitochondrial sex-differences and decipher their role in the glucose metabolism response in male and female mice comparing normal and diabetic conditions.
In the framework of this project, we are offering a TFM.
The student will perform his/her master thesis studying the mitochondrial sex-differences. In particular, the student will deeply study:
- mitochondrial respiration
- mitochondrial electron transport chain organization
- mitochondrial respiratory chain activities
- mitochondrial shape
Applicants must have a very good academic record. We are looking for organized, enthusiastic, and committed people with pro-active attitude to learn and explore new ideas. Knowledge of English are required.