GIBI

NANOPARTICLES COATED WITH CELL MEMBRANES FOR BIOMEDICAL APPLICATIONS

AIM

The aim of this project is to develop a new approach for producing nanoaprticles and exploring them as novel drug delivery systems. During the present TFM it is intended to synthesise mesoporous silica nanoparticles, which present a high controllable drug loading and release capacity, and cover them with different lipid membranes from diverse cells. Their release kinetics and their potential tumour-tropic properties will be explored and, in particular, particularly, their preferential accumulation in certain tumour cells and tissues

METHODOLOGY:
Synthesis and characterisation of mesoporous silica nanoparticles (MSNs)
NMS coating with specific cell membranes
Evaluation of their loading and release capacity of certain therapeutic agents.
Exploring their possible preferential accumulation in certain tumour cells or tissues.

REFERENCES:

M. Manzano, M. Vallet-Regí. MESOPOROUS SILICA NANOPARTICLES IN NANOMEDICINE APPLICATIONS. J. Mater. Sci. Mater. Med. 29 (5), 65 (2018).
A. Baeza, M. Manzano, M. Colilla, M. Vallet-Regí. RECENT ADVANCES IN MESOPOROUS SILICA NANOPARTICLES FOR ANTITUMOR THERAPY: OUR CONTRIBUTION. Biomater. Sci. 4, 803–813 (2016).