Translational Omics in cardio-renal disease
Cardiovascular Biology and Cardiovascular Diseases
Hospital Universitario Fundación Jiménez Díaz
DESCRIPTION OF THE OFFER
The main research areas of the group are: 1) Identification of diagnostic and prognostic molecular markers of cardio-renal disease by proteomics and metabolomics; 2) Discovery of novel interaction networks between proteins and metabolites (systems biology); 3) Development of novel analytical strategies for biomarkers quantitation in biological matrices based on Mass Spectrometry.
Thoracic Aortic Aneurysm (TAA) is a progressive dilatation of the thoracic aorta, silent and asymptomatic, and a major cause of morbidity and mortality. Physiopathological mechanisms are unknown, its diagnosis is fortuitous, and treatment mainly consists on prophylactic surgery. In collaboration with international teams, we aim to identify protein and metabolic alterations in the human aorta that reflect TAA formation and progression and with diagnostic potential when measured in blood.
The student will be involved in this and other projects related to the identification of novel markers of cardiovascular risk. Capacity in developing novel methodologies for proteomic and metabolomic analysis by Mass Spectrometry will be also acquired.