Chemical Biology and Biocatalysis
Instituto de Catálisis y Petroleoquímica CSIC (ICP)
DESCRIPTION OF THE OFFER
One of the most important problems in a tooth is the demineralization of enamel. Dental enamel is the hardest material formed by vertebrates, composed in more than 95% by an inorganic hydroxyapatite material (HAp), and less than 2% of organic material. This is not capable of self-repairing since the enamel is acellular and avascular. This usually loses its mineral material (HAp) due to decay, trauma or erosion. In this way the restoration and regeneration of damaged parts of the tooth using new materials is a relatively new area although its use is not completely satisfactory yet. One of the strategies is biomimetic mineralization, using methodologies that mimic the natural mineralization process. In this sense, several of the few strategies developed today focus on the use of hydroxyapatite.
This project is focused on the development of an innovative methodology to obtain a new type of adhesion nanobiomaterial, nanobioadhesive, with excellent stability properties, self-adhesion and rapidity in the healing process in the regeneration of tooth enamel. For this purpose, it is planned to develop an economically efficient biotechnology based on the conjugation of a protein and a metal (Ca) in the presence of phosphate to create nanoparticles of HAp in situ on the structure of the protein that would act as a matrix.
Jose Miguel Palomo