Grupo de Melanoma, CNIO

The long-term goal of the Soengas Laboratory is to translate basic research in melanoma into the clinic by identifying novel tumour markers and drug targets. Her group is particularly interested in mechanisms of cellular stress (involving apoptosis, senescence and lysosomal-mediated degradation) that being selectively deregulated in melanoma, define lineage-specific vulnerabilities (publications in Science, Cell, Cancer Cell, Nature Cell Biology, Nature Communications, among others). Her group has also generated first-in-class lymphoreporter mice for non-invasive imaging of pre-metastatic niches in melanoma (Nature).

Two positions are opened for TFM ("trabajo fin de máster") to characterize new drivers of melanoma progression that mediate the crosstalk between tumor cells and the immune system. Ultimately, the objective is to define targets for the development of more efficient anti-cancer agents.