Pathophysiology and Therapy of Immune and Inflammatory Diseases
Centro Nacional de Investigaciones Cardiovasculares "Carlos III" (CNIC)
DESCRIPTION OF THE OFFER
Research line: Sensing infection and tissue damage affects myeloid cell metabolic plasticity.
Summary: The student will help to explore how sensing infection and cell death affects the metabolic status and mitochondrial metabolic plasticity on myeloid cells. Our preliminary data show that pathogen sensing affects the metabolism of the myeloid cell with possible implications on myeloid cell function as the basis for innate and adaptive immune responses. We hypothesize that the sensing of cargo´s nature upon phagocytosis dictates a metabolic switch in myeloid cells. The student will learn many techniques working in vitro (cell culture, biochemistry, flow cytometry, cell metabolic assays, and Immunology techniques) and will learn about the in vivo models that we are developing in the lab to address this problem. The student will also be intellectually involved in the discussions and implications of this work for opening new avenues in the modulation of inflammation, immunity and tolerance. http://www.cnic.es/es/inflamacion/inmunobiologia/index.php