Protein NMR group

SCIENTIFIC AREA
Protein Structure and Function
Center
Instituto de Química Física "Rocasolano" CSIC (IQFR)
VACANCIES
1
CONTACT E-MAIL
majimenez@iqfr.csic.es
DESCRIPTION OF THE OFFER

NMR insights into peptide structures and peptide/membrane interactions

Nowadays the main challenge of structural biology is the understanding at atomic level the intricate network of biomolecular interactions, which regulate all the biological processes in healthy organisms. To this aim, a fruitful approach followed in our group (http://rmnpro.iqfr.csic.es) is the design and structural characterization of peptide models. These simplified peptide models have proven successful to deepen our knowledge about protein structure and stability. Currently, we are applying a minimalist strategy to get insights into the complex protein/membrane interactions. 

In this context, the proposed work will consist in the structure determination of some peptides models, i.e., peptides derived from pneumococcal LytA, in aqueous solution and in membrane-mimetic media. The structural study will be performed using mainly NMR and complemented by other biophysical techniques, such as circular dichroism and fluorescence.  

MASTER
Biomolecules & Cell D.
SUPERVISOR TFM
M. Angeles Jimenez