Protein NMR group
Protein Structure and Function
Instituto de Química Física "Rocasolano" CSIC (IQFR)
DESCRIPTION OF THE OFFER
NMR insights into peptide structures and peptide/membrane interactions
Nowadays the main challenge of structural biology is the understanding at atomic level the intricate network of biomolecular interactions, which regulate all the biological processes in healthy organisms. To this aim, a fruitful approach followed in our group (http://rmnpro.iqfr.csic.es) is the design and structural characterization of peptide models. These simplified peptide models have proven successful to deepen our knowledge about protein structure and stability. Currently, we are applying a minimalist strategy to get insights into the complex protein/membrane interactions.
In this context, the proposed work will consist in the structure determination of some peptides models, i.e., peptides derived from pneumococcal LytA, in aqueous solution and in membrane-mimetic media. The structural study will be performed using mainly NMR and complemented by other biophysical techniques, such as circular dichroism and fluorescence.
Biomolecules & Cell D.
M. Angeles Jimenez