Protein NMR group

NMR insights into the structures and interactions of peptides and proteins of biomedical interest

Nowadays the main challenge of structural biology is the understanding at atomic level the intricate network of biomolecular interactions, which regulate all the biological processes in healthy organisms. In this context, the general aim of our group (http://rmnpro.iqfr.csic.es) is to elucidate the physicochemical principles that determine the structure, dynamics, stability, folding and recognition of peptides, proteins, and nucleic acids, with a particular focus in disease-related biomolecules. This information is essential for a detailed description of their biological function. To that end, we use mainly high resolution multidimensional nuclear magnetic resonance (NMR) spectroscopy and get additional data from various biophysical techniques, such as circular dichroism and fluorescence.

The proposed project will focus in characterizing at the molecular and atomic level structure and interactions in proteins relevant as target for the development of novel therapeutic agents, such as the human cannabinoid receptor and its protein interactors, or the human hepatic proteins NHERF1 and ICAM1.
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