PhD position available in Rome, Sapienza University - Marie Curie Innovative Training Network (ITN) H2020 Programme
Tuesday, 18 December, 2018 - 07:57
PhD position available in Rome, Sapienza University
Marie Curie Innovative Training Network (ITN) H2020 Programme,
“circular RNA biology Training Network: from biogenesis to biomarkers” circRTrain
Lab of Prof. Irene Bozzoni
circRTrain is a Marie Curie Innovative Training Network (ITN) funded by the European Commission within the Horizon 2020 program. This network of 7 academic research institutions/universities and 6 companies will provide cross-disciplinary training in experimental and computational biology for a new generation of researchers who will exploit the power of emerging technological platforms to decipher the biology of circular RNAs.
The lab of Irene Bozzoni, placed in Rome at the Sapienza University, will focus on: circRNA function in muscle and motor neuron differentiation and related diseases
The objectives are:
a) study the role of circRNAs in cell differentiation;
b) analyze whether deregulation of circRNAs is involved in the pathogenesis of different muscle (Duchenne Muscular Dystrophy, Rhabdomyosarcoma) or neurodegenerative (Amyothrophic Lateral Sclerosis) diseases;
c) dissect circRNA function through the production of cellular and animal KO model systems;
d) analyze the ability of circRNAs to be translated (Legnini I. et al, Mol Cell, 2017)
e) set up conditions for circRNA pull down and purification of interacting factors.
Starting date: early 2019