MOLECULAR MECHANISMS OF AUTOPHAGY
Cellular Organization and Control
Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC-UAM (IIBM)
DESCRIPTION OF THE OFFER
Autophagy is an intracellular degradative pathway essential for cell homeostasis and related with numerous diseases and aging. This process is well-conserved and can be conveniently studied in simple models such as the social amoeba Dictyostelium, in which the cellular and physiological consequences of autophagy dysfunction can be studied in a whole organism. BPAN (Beta propeler-associated neurodegeneration) is a rare disease caused by mutations in the autophagic protein WIPI4. Knock out of the homologous WIPI proteins will be generated and studied in the Dictyostelium model. Other alternative projects may include the analysis of the Atg1 kinase complex that regulates autophagy in all eukaryotes.
Biomolecules & Cell D.