Experimental models of neurodegenerative diseases associated with defective autophagy

SCIENTIFIC AREA
Cellular Organization and Control
CENTER
Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC-UAM (IIBM)
VACANCIES
1
CONTACT E-MAIL
ovincent@iib.uam.es
DESCRIPTION OF THE OFFER

Autophagy is an intracellular degradation mechanism involved in several neurodegenerative diseases such as beta-propeller protein-associated neurodegeneration (BPAN). Mutations in the WIPI4/WDR45 gene are responsible for this disease. Our main goal is to determine the function of this protein in autophagy. WIPI proteins are evolutionarily conserved and we use a combination of a model organism (S. cerevisiae) and human cell lines (edited by CRISPR/Cas9) to analyze their function and to identify their interactome.

MASTER
Biomolecules & Cell D.
Molecular Biomedicine
Biotechnology