CNIC PhD offer: Investigating the impact of Hypoxia in Kawasaki disease

CNIC PhD offer: Investigating the impact of Hypoxia in Kawasaki disease

Investigating the impact of Hypoxia in Kawasaki disease: identification of novel biomarkers and molecular & genetic basis of its pathogenesis

IP: Dr. Silvia Martín-Puig
Spanish National Center for Cardiovascular Research – CNIC -
Ramon y Cajal Institute for Clinical Research –IRYCIS-

The Candidate We are looking for a motivated and determined researcher to join our group through the pFIS call: ISCIII Predoctoral Fellowhip linked to the project PI17/01817: “Hypoxia and Kawasaki disease: identification of novel biomarkers and molecular/genetic basis of its pathogenesis”. Eligible candidates must hold a Bachelor and Master Degree in Biomedical Sciences (Biology, Biochemistry, Biotechnology, Medicine, etc) and should have availability to be enrolled in a PhD Program to begin in 2018-2019. Good English communication skills are mandatory. Previous research experience will also be valued.

The Project The project aims to investigate the importance of hypoxia in the initiation and evolution of Kawasaki disease (KD) and to identify new biomarkers to improve its diagnosis. KD is a pediatric vasculitis of unknown origin that affects small- and medium-size blood vessels and higher incidence of the coronary arteries that could dilate and form giant aneurysms with the concomitant risk of heart failure. The lab of Dr.Martin-Puig has generated a mouse model with altered activation of the hypoxia pathway that recapitulates the clinical cardiovascular manifestations of KD. The student will investigate the molecular mechanisms responsible for vascular inflammation in the murine model and evaluate the activation of the hypoxia pathway in human samples provided by medical collaborators of the group. The candidate will be exposed to a multidisciplinary environment working with biologists, biochemists, bioinformaticians and clinicians and will gain knowledge in molecular and cellular biology, animal handling and human clinical research.

The Center The project will be carried out at CNIC and IRYCIS in Madrid. CNIC is a leading international institution dedicated to investigate the basis of cardiovascular health and disease and to translate this knowledge into improved patient care. CNIC counts with last generation technology and excellent core facilities. IRYCIS is a clinical foundation committed to excellence in biomedical research in the context of Hospital Ramon y Cajal in Madrid, with more than 200 open collaborations with public and private entities towards an improvement in human disease treatment.

Qualified applicants should submit an updated CV to Cristina Gimenez ( before March 7th 2018 indicating Ref: SMP-ISCIII Predoctoral Fellowhip/ PI17/01817.