Physiopathology of atherogenesis

Immunobiology of atherotrombosis

According to the World Health Organization, cardiovascular diseases are the first cause of death globally and atherosclerosis underpins most of the incidence. It is a chronic disease characterized by progressive retention of lipids in the arterial wall and an exacerbated inflammatory response. The TFM will help establishing a role for the immune receptor nucleotide-binding oligomerization domain 1 (NOD1) in the context of atherosclerosis. To perform this project, our lab will provide flow cytometry, immunofluorescence, mouse genetics and in vitro and in vivo functional assays.