Nuclear Receptor Signaling

SCIENTIFIC AREA
Pathophysiology and Therapy of Immune and Inflammatory Diseases
CENTER
Centro Nacional de Investigaciones Cardiovasculares "Carlos III" (CNIC)
VACANCIES
1
CONTACT E-MAIL
cgimenez@cnic.es
DESCRIPTION OF THE OFFER

Scientist/Supervisor: Mercedes Ricote

Research line 1: Role of macrophage nuclear receptors in cardiac homeostasis and injury.

Summary: Activation of the immune system is a good candidate for triggering tissue regeneration; however the molecular pathways that directly link the immune system to myocardial regeneration remain poorly understood. In this project, we will focus on the role of macrophage nuclear receptors (NRs) in cardiac homeostasis, and in the inflammatory response after myocardial infarction. We will use tissue-specific knockouts, transcriptomics, in vivo imaging, and the latest techniques in cell-fate mapping to unravel the role of macrophages in cardiovascular physiology.

Scientist/Supervisor: Mercedes Ricote

Research line 2: Transcriptional regulation of nuclear receptors in macrophages.

Summary: Our laboratory is using genome wide studies to decipher the contribution of nuclear receptors to the macrophage functions and the pathogenesis of human diseases. The project will focus on analysis of data derived from the application of chromatin immunoprecipitation coupled to massively parallel sequencing (ChIP-Seq) and high throughput transcriptomic data to build pathway models for differentially regulated genes that will help us to define the molecular mechanism of nuclear receptor actions in macrophage biology. The student will need some prior knowledge of R and/or Python programming.

 

 

MASTER
Biomolecules & Cell D.
EXTRA SUPERVISOR
María Piedad Mendéndez Gutiérrez