Citogenética Molecular e Ingenieria Genómica

Chromosomal translocations are very common events involved in the development of several cancers, especially in sarcomas and haematological malignancies. The research activity of the Molecular Cytogenetics and Genome Editing Unit covers the main topics related to cancer cytogenetics and genome engineering: from classical cytogenetics techniques to new genome engineering tools, including the CRISPR-Cas9 system. We are focusing on the implementation and development of new technologies to enhance knowledge about the biology of tumours and to discover new potential therapeutic targets. With combined use of CRISPR-Cas9 genome editing and cellular technologies, we are creating in vitro models that recapitulate chromosomal and genetic cancer alterations.