Desarrollo linfohematopoyético humano
Centro de Biología Molecular “Severo Ochoa” CSIC-UAM (CBMSO)
DESCRIPTION OF THE OFFER
The group offers master students the opportunity to get involved in a project related with the general aim of the lab "understanding the molecular mechanisms that control physiological and pathological T-cell development in humans" . Using gain- and loss-of-function approaches, special emphasis will be made on understanding the role of the NOTCH1 signaling pathway and some of its targets (IL-7R, pTalpha, cmyc, CD44, cyclinD1, p21...) in T-cell commitment and differentiation, as well as in the pathogenesis of T-cell transformation, particularly, of T-cell acute lymphoblastic leukemia. Likewise, the role of NOTCH regulators, including miRNAs and Sfrp1 Wnt-related factors, will be analyzed in T-cell phyisiology and pathology. The final aim is to identify specific molecular targets of NOTCH function, susceptible of therapeutic manipulation, and to provide proof of concept of their suitability for translational approaches using preclinical animal models.