Antigen presenting cells and inflammatory bowel disease
Pathophysiology and Therapy of Immune and Inflammatory Diseases
Hospital Universitario de La Princesa
DESCRIPTION OF THE OFFER
Antigen presenting cells (APC), including dendritic cells (DC) and macrophages (MΦ), determine the outcome (pro-inflammatory/tolerogenic) of antigen specific immune responses. In the gastrointestinal tract, APC maintain the mechanism of immune tolerance towards nutrients/commensals while initiate active responses towards invading antigens. Changes in such delicate balance are related with development of inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, where APC initiate and perpetuate an abnormal immune response towards the commensals.
Recent evidence from the last years has revealed that both intestinal DC and MΦ can be divided into subsets, being their proportions altered in the IBD patients. However, the exact function of each DC/MΦ subset together with their specific role in IBD progression remains elusive. In this project, we will characterize the phenotype and function of human intestinal MΦ subsets both in healthy controls and in IBD patients and identify the mechanisms mediating the modulation elicited by the intestinal microenvironment. To that aim, the specific aims of this project will be:
- Characterize the phenotype and function of the intestinal MΦ subsets.
- Identify the mechanisms that mediate their mucosal recruitment from their circulating precursors (monocytes).
- Evaluate the effect that several secreted microbiota peptides, that we have identified, elicit on the phenotype and function of human intestinal MΦ.
Biomolecules & Cell D.