Mechansimo of Neurodegenertion
Molecular and Cellular Neurobiology
Centro de Biología Molecular “Severo Ochoa” CSIC-UAM (CBMSO)
DESCRIPTION OF THE OFFER
Our group is analyzing molecular mechanisms of degeneration and we are focused on the role of PI3K-Akt in neurodegeneration. We are using cellular and murine models of neurodegeneration , such as transgenic mouse model of Alzheimer Diseases, and Ischemia model. We are currently analyzing the role of Akt isoforms (Akt1, 2 and 3), we studied the role of these kinases in differentiation process and now we are analyzing the role of each isoform controlling proliferation in neurons and in glia. We are now focused on some Akt downstream elements, controlling proteostasis, mechanism altered in neurodegeneration.
Biomolecules & Cell D.
Drª Lara Ordoñez