Grupo de Neurobiología-GNDe
Molecular and Cellular Neurobiology
Instituto Cajal CSIC
DESCRIPTION OF THE OFFER
At the GNDe, we are particularly interested in the formation of myelin during CNS development, the pathogenic basis of demyelination and the developmental cellular and molecular pathways that up-regulate in Multiple Sclerosis and demyelinating lesions, in general. The main focus for our current research lines are Oligodendrocyte Precursor Cells (OPCs): from these cells, mature oligodendrocytes derive during embryonic and postnatal development. Besides this, among 3-8% of the total number of cells in the adult CNS are OPCs (also known as a-OPCs) and they are able to give rise to newly-generated adult myelin-forming oligodendrocytes both in physiological conditions (they have become as main actors for learning and plasticity for current and future Neurobiology) as well as spontaneous reaction against damage (indeed, they give rise to demyelinated lesions -"shadow plaques"-, which are capital in the clinical evolution of the disease).
We offer a position to work in oligodendrogliogenesis during development and in the adult, studying the physiology of OPCs in different context either in vitro and in vivo.
Biomolecules & Cell D.