Redox signalling and proteomics in the response to hypoxia
Molecular Medicine and Health Biotechnology
Hospital Universitario de La Princesa
DESCRIPTION OF THE OFFER
The research lines of the group include application of thiol redox proteomics to different pathophysiological scenarios, as well as the study of redox signalling in the response to acute hypoxia.
The offer is included in this second line, where we have recently uncovered the role of mitochondrial complex I and the mitochondrial sodium/calcium exchanger NCLX as key components of the reaactive oxygen species (ROS) production in the response to hypoxia (manuscript under second review).
We continue this research line, further studying the mechanism of ROS production in hypoxia/ischemia and in reperfusion, and exploring clinical applications by reducttion of oxidative damage in cardiac infarction or stroke.
Biomolecules & Cell D.