Telomere homeostasis in Drosophila melanogaster
Developmental Molecular Biology
Departamento de Biología Molecular (UAM)
DESCRIPTION OF THE OFFER
We are interested in studying telomere homeostasis in the fruit fly Drosophila melanogaster. Drosophila telomeres are composed of a conserved subtelomeric sequence (mainly repetitive satellite sequences) followed by an array of retrotransposons which are protected by a cap domain. Telomere lenght is maintained by a phenomenon of transposition that implies transcription of the transposons, translocation to the cytoplam and reentry to the nucleus to be retrotransposed. This mechanism needs to be highly regulated, and we have strong indications that such regulation is exerted, at least in part, by long non-coding RNAs that arise from the subtelomeric region. One of the main aims of my laboratory is to unravel how these lncRNAs function in telomere homeostasis.
Biomolecules & Cell D.