Parvovirus pathogenesis and oncolysis

  Our research is focused in the cell-host interactions underlying Parvovirus oncotropism towards eventually designing safe infectious anti-cancer biological tools. The main viral model used in the laboratory is the parvovirus Minute Virus of Mice (MVM).

The student will perform collaborative research in the following two main topics:

1. Determine and manipulate the MVM capid domains involved in cancer cell recognition and Infection.

2.  Analysis of the protein signals and cellular factors regulating the intracellular traffic, assembly, and maturation of the MVM capsids and virions in transformed cells.