Molecular Oncology & Pathology Lab
Molecular Medicine and Health Biotechnology
Hospital Universitario La Paz
DESCRIPTION OF THE OFFER
New high-performance molecular technologies are changing the practice of medicine. Decision-making based on experience and traditional clinical-pathological parameters is being complemented by information based on the molecular characteristics of patients and their diseases. Knowledge about the whole human genome, along with the advent of new technologies –such as DNA microarrays, next-generation sequencing and mass spectrometry- and the development of bioinformatics have settled the basis for a complete molecular characterization of cancer. Molecular Oncology & Pathology Lab is focused on exploiting all these new technologies to analyze cancer from a Systems Biology perspective. This approach can help clinicians by providing diagnostic tools for cancer classification facilitate treatment decisions, monitor treatment efficacy and predict clinical outcome. This strategy can also allow identifying novel therapeutic targets.
The main objective of our research team is to detect clinically relevant questions, in close collaboration with the medical community and develop molecular tools to answer them.
● Development of new technologies for analysis of proteome and its application to the identification of new biomarkers and molecular targets in cancer.
● Analysis of gene and microRNA expression aimed at developing molecular profiles with clinical application.
● Evaluation of new sources of biomarkers from peripheral blood: miRNAs and metabolites.
● Systems Pharmacology: development of mathematical models integrating data from omics technologies to elucidate the mechanisms of action of anticancer drugs.
Biomolecules & Cell D.
Angelo Gámez Pozo