Posttranslational modification of proteins
Protein Structure and Function
Centro de Investigaciones Biológicas CSIC (CIB)
DESCRIPTION OF THE OFFER
The work of the Masters’ Project will be devoted to the study of Type III intermediate filament proteins, mainly vimentin and glial fibrillary acidic protein (GFAP), their structure-function relationships and their involvement in physiology and pathophysiology. The work will involve the generation of mutants of these proteins, the study of their behavior in vitro and in cellular models, and the assessment of their regulation by oxidative modifications and interaction with zinc. The experimental approaches will include molecular and cellular biology techniques, protein chemistry, proteomics and structural approaches.
Biomolecules & Cell D.