Morphogenesis and differentiation of vertebrate central nervous system

Project 1. Eye morphogenesis in zebrafish. We are interested in understanding the molecular mechanisms that control the specification of the retinal pigmented epithelium using molecular biology techniques combined with image analysis in living embryos.  

Project 2. Role of Shh signaling pathway in visual system morphogenesis. Combining CRISPR/Cas9 and imaging techniques, we aim at visualizing in vivo Shh signaling to study its role in proximo-distal patterning of the eye and Shh contribution to retino-tectal axonal guidance