Immunity/tolerance balance in homeostasis and disease
Pathophysiology and Therapy of Immune and Inflammatory Diseases
Hospital Universitario de La Princesa
DESCRIPTION OF THE OFFER
Data of our group indicate that signals triggered by PSGL-1/P-selectin interaction are relevant for the intestinal homeostasis and are crucial to prevent from the development of autoimmune syndromes in mice. In addition, our preliminary data suggest that this interaction could also be important for maintaining the vascular homeostasis. Our work is centered in translational projects trying to understand the implication of PSGL-1/P-Selectin interaction in the development of autoimmune and vascular diseases such as scleroderma, lupus and pulmonary arterial hypertension.