Immunity/tolerance balance in homeostasis and disease
Pathophysiology and Therapy of Immune and Inflammatory Diseases
Hospital Universitario de La Princesa
DESCRIPTION OF THE OFFER
Our group has described that the leukocyte receptor PSGL-1 is a tolerogenic receptor implicated in maintaining the immune system homeostasis. We have recently reported that PSGL-1 absence promotes the development of an autoimmune syndrome similar to human scleroderma and the absence of P-selectin, the main ligand of PSGL-1, promotes the development of a lupus-like syndrome. Interestingly, we have found that aged PSGL-1 KO female mice develop pulmonary arterial hypertension, the main cause of death of scleroderma patients, and point the relevance of PSGL-1 in maintaining the vascular homeostasis. Our research is focused in translational studies trying to understand the possible role of PSGL-1 and P-selectin in the pathogenesis of these diseases in humans.
At present, we are initiating a project to analyze the role of PSGL-1 in the generation and activation/differentation of B cells. We are also searching for alterations in PSGL-1-dependent signaling that could be implicated in the pathogenesis of scleroderma, lupus and pulmonary arterial hypertension.