Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC-UAM (IIBM)
DESCRIPTION OF THE OFFER
Title: Understanding the role of hypoxia in the regulation of angiogenesis
Angiogenesis is a fundamental process that leads to the formation of new blood vessels from pre-existing ones. It is a very active mechanism during development, yet it is highly restricted in adult tissues and aberrantly activated in cancer. Hypoxia is one of the main triggers of angiogenesis both in physiology and disease. In response to proangiogenic stimuli like hypoxia, endothelial cells (ECs) are reprogrammed to two distinct phenotypes: tip ECs and stalk ECs. Tip cells are cell cycle arrested and extend long filopodia to sense and direct the migration of the sprouting vessels towards the proangiogenic stimulus. In contrast, stalk cells are proliferative cells that provide new endothelial cells to the expanding vessels. The role of Hypoxia Inducible Factors (HIF) in reprogramming endothelial cell fate during sprouting angiogenesis has not been fully elucidated. The aim of this project is to better understand the role of hypoxia in the regulation of the proliferative response of endothelial cells and in the reprogramming of endothelial cell fate during sprouting angiogenesis.