Mitochondrial biology, bioenergetics and metabolism
Metabolism and Cell Signaling
Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC-UAM (IIBM)
DESCRIPTION OF THE OFFER
Mutations in mitochondrial or nuclear DNA that compromise the OXPHOS system are the root for a heterogeneous group of genetic inherited disorders referred as mitochondrial diseases, with no cure available. Moreover, mitochondria dysfunction has been linked to many other human disorders including aging, neurodegeneration or cancer.
The long-term goal of our lab is to understand the molecular components that regulate mitochondrial energy metabolism, in the context of physiology and diseases, and use this knowledge to develop successful therapies. We employ CRISPR/Cas9-based genetic screens in combination with multi-omics strategies (proteomics&metabolomics) and biochemical assays to uncover the fundamental pathogenic processes underlying diseases associated with mitochondrial dysfunction.
1) Balsa E et al. Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death. Nature Communications. 2020
2) Balsa E et al. ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes Through PERK/eIF2α Axis. Molecular Cell. 2019
3) Barrow JJ & Balsa E et al. Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations. Molecular Cell. 2016
Biomolecules & Cell D.
Eduardo Balsa Martínez