Molecular mechanisms of neuronal differentiation and regeneration
Molecular and Cellular Neurobiology
Centro de Biología Molecular “Severo Ochoa” CSIC-UAM (CBMSO)
DESCRIPTION OF THE OFFER
GTPases from the R-Ras subfamily are involved in celular proliferation and differentiation. Alterations in myelin synthesis produce a decrease in the myelin sheath wrapping the axons modifying their conduction capability and causing important illnesses such as Multiple Sclerosis, optic neuromyelitis and hypomyelinating leukodystrophies (ELA) among others. Demyelinating diseases present a moderate-high prevalence, presenting 60 cases each 100.000 inhabitants, this implies that in Spain more than 50.000 people suffer this kind of pathologies. Establishing the molecular bases implicated in mielination constitutes an important target for our research group.
In our laboratory we investigate the role that R-Ras subfamily members play in the regulation of differentiation and survival processes of oligodendrocytes through PI3K/AKT molecular pathway.
This Project has been financiated by the Economy, Industry and Competitivity Minister (BFU2015-64829-R).
Beatriz Cubelos Alvarez