Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC-UAM (IIBM)
DESCRIPTION OF THE OFFER
MAPK´s role in cancer and its therapy
The MAPKs signaling pathways are one of the key mechanisms that contributes to the genesis and development of cancer. Its implications in the molecular basis of cellular transformation, as oncogenic or antioncogenic mechanisms, are widely study by different laboratories. In addition, MAPK-mediated signaling pathways are involved in cancer therapy. This effect can occur on two levels. On the one hand, the different MAPK-mediated signaling pathways may be therapeutic targets in their own right, such as the new MEK1 / 2 or B-raf inhibitors, some of them currently used in cancer therapy such as sorafenib . The other role of MAPK kinases in cancer therapy is related to the cellular response to the different antitumor agents in both chemotherapy and radiotherapy.
Our central objective is to evaluate the therapeutic potential of MAPK-mediated signaling in different experimental models and its possible implication as a mechanism of chemo and radio resistance. This effect is evaluated at the level of radiotherapy, conventional chemotherapy (cisplatin, vincristine, gemcitabine, etc.) and targeted therapies (Palbociclib, sorafenib, imatinib, ect, ect). But we are also interested in how the deregulation of MAPk affects the biology of the tumor in different aspects such as proliferation, migration, invasiveness, ect .. to achive these goals we use different experimental approaches that involve the use of cell culture, techniques of biochemistry of protein And nucleic acids (western, PCR, q-.Rt-PCR, etc.), use of different expression vectors (viral, non-viral) gene editing techniques ect, etc.
The incorporation of the master students in this exciting project, will allow them a global vision of the cancer and its therapy as well as the learning of different techniques of cellular and molecular biology. The results derived from this research project could contribute to the development of new diagnostic tools, improve current cancer therapies and our knowledge of cellular transformation.
Biomolecules & Cell D.
Ricardo Sanchez Prieto