Regulation and function of proinflammatory mediators and their involvement in immune and inflammatory mediated diseases
Pathophysiology and Therapy of Immune and Inflammatory Diseases
Centro de Biología Molecular “Severo Ochoa” CSIC-UAM (CBMSO)
DESCRIPTION OF THE OFFER
Inflammatory Bowel Disease (IBD) is a chronic autoimmune disorder whose incidence is exponentially growing around the world. Disruption of the intestinal barrier integrity and alteration in the microbiota composition (dysbiosis) are common factors found in IBD patients. The physical intestinal barrier is formed by intestinal epithelial cells (IECs) to separate the microbiota from the lamina propria, but IECs also act as an active participant in innate immunity, continuously interacting with the commensal microbiota to maintain the intestinal homeostasis.
The Akt family of serine-threonine kinases regulates several cell functions and plays an essential role in inflammation and in the development of IBD.
The main goal of this project will be to analyze the role of Akt isoforms in the maintenance of the intestinal barrier and the response of IECs to bacterial components.
Biomolecules & Cell D.